What is MDR1? Its is a gene mutation that does not allow drugs to be cleared out of the brain as it would
be in the case of a dog that does not carry this mutation. This gene is involved with the blood-brain
barrier. Normally it functions in a protective way to remove drugs and toxins from the brain.
Dogs without this protective gene may suffer from abnormal nuerological distress that can cause death
and/or extended hospital treatment.
What are the symptoms? Excessive salivation, blindness, coma, respiratory distress,
ataxia (the loss of muscle co-ordination) and death.
There is a DNA test available for this mutation.
It is called the MDR1 Test, and can be done by taking a cheek swab from your dog, at home.
The cost of this test is $60.00. Your vet can also do this for you if you give him the information,
or take the test kit in with you. The test sample is sent to the university by regular mail.
All Collies do not carry this gene, and some test normal for this condition.
Click below to order a test kit & read more information. The kit is free.
WASHINGTON STATE UNIVERSTITY TEST KIT & ORDER INFORMATION
As you see below this gene does not affect only Collies, and more breeds and more drugs will
probably be added to this list in the future, and we learn more and more.
Collies, as well as Shetland Sheepdogs, Australian Shepherds, German Shepehrds, Old English Sheepdogs
Border Collies and other breeds, as well as mixes may react to the drugs below.
Problem drugs:
ACEPROMAZINE, tranquilizer
BUTORPHANOL, pain reliever
CYCLOSPORIN, immunosuppressive drug
DIGOXIN, heart drug
DOXORUBICIN, cancer drug
IVERMECTIN, a wormer
LOPERAMIDE - Imodim, an over-the-counter anti-diarheal
VINBLASTINE, cancer drug
VINCRISTINE, cancer drug
Drugs that may be potential problem drugs:
DOMPERIDONE
ETOPOSIDE
MITOXATRONE
MORPHINE
ONDANSETRON
PACLITAXEL
QUINIDINE
RIFAMPICIN
be in the case of a dog that does not carry this mutation. This gene is involved with the blood-brain
barrier. Normally it functions in a protective way to remove drugs and toxins from the brain.
Dogs without this protective gene may suffer from abnormal nuerological distress that can cause death
and/or extended hospital treatment.
What are the symptoms? Excessive salivation, blindness, coma, respiratory distress,
ataxia (the loss of muscle co-ordination) and death.
There is a DNA test available for this mutation.
It is called the MDR1 Test, and can be done by taking a cheek swab from your dog, at home.
The cost of this test is $60.00. Your vet can also do this for you if you give him the information,
or take the test kit in with you. The test sample is sent to the university by regular mail.
All Collies do not carry this gene, and some test normal for this condition.
Click below to order a test kit & read more information. The kit is free.
WASHINGTON STATE UNIVERSTITY TEST KIT & ORDER INFORMATION
As you see below this gene does not affect only Collies, and more breeds and more drugs will
probably be added to this list in the future, and we learn more and more.
Collies, as well as Shetland Sheepdogs, Australian Shepherds, German Shepehrds, Old English Sheepdogs
Border Collies and other breeds, as well as mixes may react to the drugs below.
Problem drugs:
ACEPROMAZINE, tranquilizer
BUTORPHANOL, pain reliever
CYCLOSPORIN, immunosuppressive drug
DIGOXIN, heart drug
DOXORUBICIN, cancer drug
IVERMECTIN, a wormer
LOPERAMIDE - Imodim, an over-the-counter anti-diarheal
VINBLASTINE, cancer drug
VINCRISTINE, cancer drug
Drugs that may be potential problem drugs:
DOMPERIDONE
ETOPOSIDE
MITOXATRONE
MORPHINE
ONDANSETRON
PACLITAXEL
QUINIDINE
RIFAMPICIN
| You can also help by reporting any drug reaction your dog has, no matter what breed, to the university. Researchers suspect that many other breeds and many other drugs will be added to the lists as more research is done. |
| Drug Sensitivy in Collies |
| You may want to do on your Collie, whether a showdog or not, because it will determine if your dog is sensitive to certain commonly used drugs that are causing mild to lethal reactions in many dogs today |